Honorable Mention: Sphere Grid If you have a creature that can get in for damage once, getting in for damage becomes significantly easier with the creature becoming bigger and gaining trample
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1 Galadriel's Dismissal Protect Your Realm Single-target protection spells like Legolass Quick Reflexes are great for keeping one creature safe, but if youre looking to keep everything you control safe, Galadriels Dismissal is the best choice
Then Day of Black Sun will destroy all of these things with that mana or less