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Rob: Yeah pretty much anything you have

If I have a card that I spent $1500 on a year or two ago, and I invested that money, because the company said they wouldn't print any more ever, and then the price rises to $3100 for its condition, and then they announce the removal of the Reserve List tomorrow, and by the end of the week we see that it's going to be a mythic rare in Eternal Masters 2, I think that would be the worst feel bad moment ever

Blue and red have both had positive relationships with artifacts mechanically in the past (in addition to red's ability to destroy them)

Unless that signatures from a big-time Magic name or artist, its unlikely that getting your cards signed will have a positive effect on the grading or value of that card