You can get a Swords to Plowshares to exile a creature thats indestructible, a Boros Charm to make your permanents indestructible until the end of the turn, or a Generous Gift to destroy any big, bad permanent and leave your opponent with a 3/3 Elephant instead
If you have a card that says all your goblins get a bonus, and the card in question says it's a goblin on the type line , you know you're good to go
The flip condition is tough to make happen, but not impossible
Liliana, the Last Hope One of the games most popular anti-heroes, Liliana returns with what may not quite be her most powerful form (looking at you, Liliana of the Veil), but one that has seen significant play: Liliana, the Last Hope won her debut Pro Tour (Pro Tour Eldritch Moon) flavourfully against the cosmic horror threat of Emrakul, the Promised End, with seven copies of the planeswalker featuring in the top 8