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- CAS Number: 2307477-23-0 Molecular Formula: C18H22ClN3O5 Molecular Weight: 395
Proteolysis targeting chimera (PROTAC) building block
701 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCCOCCOCCOCCN=[N]#N)=[N+](C)C)=C1
Product Name BG-DOTA-tris(t-Bu) Synonyms SNAP-DOTA-tris(t-Bu) CAS Number n/a Related CAS Molecular Formula C41H64N10O8 Molecular Weight 825
Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:25mg - CAS Number: 2307477-23-0 MolecularSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by
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