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Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE Size:1mg Product Name DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4) Synonyms CAS

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Description

Product Name DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C60H85N7O16 Molecular Weight 1160

S)-AHPC-CO-PEG3-propargyl Synonyms CAS Number 2374122-30-0 Related CAS Molecular Formula C32H44N4O7S Molecular Weight 628

researchers fused Escherichia coli dihydrofolate reductase (eDHFR) to a chimeric antigen receptor (CAR) and demonstrated that this fusion does not disrupt cell signaling or the CAR’s cytotoxic function

Structural basis for the action of the drug trametinib at KSR-bound MEK

Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4)-MMAE Size:1mg Product Name DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG4) Synonyms CASSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a

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