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Trametinib binds KRS-MEK and disrupts RAF-MEK
and casein kinase 1a (CK1a)
Product Name Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8)-PNP Synonyms CAS Number Related CAS Molecular Formula C57H85N9O23 Molecular Weight 1264
235 SMILES BrCCCC(=O)NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG8) dota Trametinib binds KRS-MEK and disruptsSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. Derived
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