Propargy-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP Size:25mg Chloroquinaxoline sulfonamide (CQS) promotes the

Chloroquinaxoline sulfonamide (CQS) promotes the recruitment of RBM39 (RNA binding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase for degadation

Its fluorescence is relatively pH-insensitive

Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates

8 SMILES ClCCOCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Propargy-Gly(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP Size:25mg Chloroquinaxoline sulfonamide (CQS) promotes theSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing