Hailing from New Zealand-based Legend Story Studios, Flesh and Blood sees players choose a single hero to play with, equipping them with items and weapons that are used to attack the other players hero who of course has their own associated cards to attack and defend with
Don't worry, you'll end up playing most of them with all the ramp you'll be getting from your commander

Hans, Run!" Agency Outfitter Ajani's Aid Alpine Houndmaster Angel's Herald Angrath's Fury Arachnus Spinner Ashiok's Forerunner Asmoranomardicadaistinaculdacar Avarax Basri's Aegis Behemoth's Herald Bogbrew Witch Chandra's Firemaw Chandra's Flame Wave Chandra's Outburst Dark Supplicant Daru Cavalier Demon's Herald Diligent Farmhand Domri's Nodorog Dovin's Dismissal Dragon's Approach Dragon's Herald Dragonstorm Forecaster Elspeth's Devotee Elspeth, Undaunted Hero Elvish Clancaller Embermage Goblin Ethereal Elk Forging the Tyrite Sword Garruk's Warsteed Gate to the Afterlife Gideon's Battle Cry Gideon's Resolve Gigantiform Goblin Tutor Goldmane Griffin Grand Master of Flowers Grasping Current Growth-Chamber Guardian Infectious Bloodlust Isperia the Inscrutable Jace's Ruse Journey for the Elixir Kassandra, Eagle Bearer Kyscu Drake Liberating Combustion Liliana's Influence Liliana's Scorn Llanowar Sentinel Magitek Infantry Nazahn, Revered Bladesmith Niambi, Faithful Healer Nissa Revane Nissa's Encouragement Oko's Hospitality Ral's Dispersal Raven Clan War-Axe Renowned Weaponsmith Rhythmic Water Vortex Rowan's Stalwarts Ruin in Their Wake Say Its Name Screaming Seahawk Shadowborn Apostle Shaun & Rebecca, Agents Sift Through Sands Silver Surfer, Galactus's Herald Smuggler Captain Sorin's Guide Sphinx Ambassador
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For example, you can have four Ashiok, Nightmare Muses and four Ashiok, Dream Renders in your deck (depending on the format and legality of the cards, of course)