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9 nM in cell-free assays for APPL and Notch cleavage
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GW788388 75cm 9 nM in cell-free assaysGW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM in a cell free assay, also inhibits TGF ? type II receptor and activin type II receptor activities, but does not inhibit BMP type II receptor.
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